Expression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones
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چکیده
منابع مشابه
The Effect of Resistance Training Along with Royal Jelly Supplementation on Expression of Nerve Growth Factor and Tyrosine Kinase A Receptor in the Hippocampal Tissue of Alzheimer's Rats
Introduction: Current study aimed to investigate the effects of resistance training (RT) along with royal jelly (RJ) supplementation on hippocampal expression of nerve growth factor (proNGF) and p75 receptor in a rat’s model of Alzheimer's disease. Method: 42 male Sprague-Dawley rats were treated with Trimethyltin chloride (8 mg/kg). Then, the rats were randomly divided into seven equal group...
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Nerve growth factor (NGF) is a neurotrophic factor that is functional in the survival, maintenance and differentiation of nervous system cells. This protein has three subunits, of which the beta subunit has the main activity. Its structure consists of a cysteine knot motif made up of beta strands linked by disulfide bonds. It can be used as a therapeutic agent in the treatment of many diseases....
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متن کاملK-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity.
The rat pheochromocytoma PC12 cell line differentiates into a sympathetic neuronal phenotype upon treatment with either nerve growth factor (NGF) or basic fibroblast growth factor. The alkaloid-like compound K-252a has been demonstrated to be a specific inhibitor of NGF-induced biological responses in PC12 cells (Koizumi, S., Contreras, M. L., Matsuda, Y., Hama, T., Lazarovici, P., and Guroff, ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1993
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.90.23.10984